Analysis and processing of mechanically stimulated electrical signals for the identification of deformation in brittle materials

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The fracture of brittle materials is of utmost importance for civil engineering and seismology applications. A different approach towards the aim of early identification of fracture and the prediction of failure before it occurs is attempted in this work. Laboratory experiments were conducted in a variety of rock and cement based material specimens of various shapes and sizes. The applied loading schemes were cyclic or increasing and the specimens were tested to compression and bending type loading of various levels. The techniques of Pressure Stimulated Current and Bending Stimulated Current were used for the detection of electric signal emissions during the various deformation stages of the specimens. The detected signals were analysed macroscopically and microscopically so as to find suitable criteria for fracture prediction and correlation between the electrical and mechanical parameters. The macroscopic proportionality of the mechanically stimulated electric signal and the strain was experimentally verified, the macroscopic trends of the PSC and BSC electric signals were modelled and the effects of material memory to the electric signals were examined. The current of a time-varying RLC electric circuit was tested against experimental data with satisfactory results and it was proposed as an electrical equivalent model. Wavelet based analysis of the signal revealed the correlation between the frequency components of the electric signal and the deformation stages of the material samples. Especially the increase of the high frequency component of the electric signal seems to be a good precursor of macrocracking initiation point. The additional electric stimulus of a dc voltage application seems to boost the frequency content of the signal and reveals better the stages of cracking process. The microscopic analysis method is scale-free and thus it can confront with the problems of size effects and material properties effects. The AC conductivity time series of fractured and pristine specimens were also analysed by means of wavelet transform and the spectral analysis was used to differentiate between the specimens. A non-destructive technique may be based on these results. Analysis has shown that the electric signal perturbation is an indicator of the forthcoming fracture, as well as of the fracture that has already occurred in specimens.The National Foundation of Scholarships (IKY) Greec

Analysis and processing of mechanically stimulated electrical signals for the identification of deformation in brittle materials

The fracture of brittle materials is of utmost importance for civil engineering and seismology applications. A different approach towards the aim of early identification of fracture and the prediction of failure before it occurs is attempted in this work. Laboratory experiments were conducted in a variety of rock and cement based material specimens of various shapes and sizes. The applied loading schemes were cyclic or increasing and the specimens were tested to compression and bending type loading of various levels. The techniques of Pressure Stimulated Current and Bending Stimulated Current were used for the detection of electric signal emissions during the various deformation stages of the specimens. The detected signals were analysed macroscopically and microscopically so as to find suitable criteria for fracture prediction and correlation between the electrical and mechanical parameters. The macroscopic proportionality of the mechanically stimulated electric signal and the strain was experimentally verified, the macroscopic trends of the PSC and BSC electric signals were modelled and the effects of material memory to the electric signals were examined. The current of a time-varying RLC electric circuit was tested against experimental data with satisfactory results and it was proposed as an electrical equivalent model. Wavelet based analysis of the signal revealed the correlation between the frequency components of the electric signal and the deformation stages of the material samples. Especially the increase of the high frequency component of the electric signal seems to be a good precursor of macrocracking initiation point. The additional electric stimulus of a dc voltage application seems to boost the frequency content of the signal and reveals better the stages of cracking process. The microscopic analysis method is scale-free and thus it can confront with the problems of size effects and material properties effects. The AC conductivity time series of fractured and pristine specimens were also analysed by means of wavelet transform and the spectral analysis was used to differentiate between the specimens. A non-destructive technique may be based on these results. Analysis has shown that the electric signal perturbation is an indicator of the forthcoming fracture, as well as of the fracture that has already occurred in specimens.EThOS - Electronic Theses Online ServiceNational Foundation of Scholarships (IKY) GreeceGBUnited Kingdo

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21

Cardiac metabolism affects systemic energetic balance. Previously, we showed that Kriippel-like factor (KLF)-5 regulates cardiomyocyte PPAR alpha and fatty acid oxidation-related gene expression in diabetes. We surprisingly found that cardiomyocyte-specific KLF5 knockout mice (alpha MEIC-KLF5(-/-)) have accelerated diet-induced obesity, associated with increased white adipose tissue (WAT). Alterations in cardiac expression of the mediator complex subunit 13 (Med13) modulates obesity. alpha MHC-KLF5(-/-) mice had reduced cardiac Med13 expression likely because KLF5 upregulates Med13 expression in cardiomyocytes. We then investigated potential mechanisms that mediate cross-talk between cardiomyocytes and WAT. High fat diet-fed alpha MHC-KLF5(-/-) mice had increased levels of cardiac and plasma FGF21, while food intake, activity, plasma leptin, and natriuretic peptides expression were unchanged. Consistent with studies reporting that FGF21 signaling in WAT decreases sumoylation-driven PPAR gamma inactivation, alpha MHC-KLF5(-/-) mice had less SUMO-PPAR gamma in WAT. Increased diet-induced obesity found in aMHC-KLF5-/- mice was absent in alpha MHC-[KLF5(-/-);FGF21(-/-)] double knockout mice, as well as in alpha MHC-FGF21(-/-) mice that we generated. Thus, cardiomyocyte-derived FGF21 is a component of pro-adipogenic crosstalk between heart and WAT